Search results for "Retinoid receptor"

showing 3 items of 3 documents

Function of RAR? and RAR?2 at the initiation of retinoid signaling is essential for avian embryo survival and for distinct events in cardiac morphoge…

2003

Avian embryogenesis requires retinoid receptor activation by the vitamin A active form, retinoic acid (RA), during neurulation. We conducted loss-of-function analysis in quail embryos by nutritional deprivation of RA and by blocking generation of retinoid receptors. Here we identify a distinct role for RARα2 in cardiac inflow tract morphogenesis and for RARγ in cardiac left/right orientation and looping morphogenesis. Blocking normal embryos with antisense oligonucleotides to RARα2 or RXRα diminishes GATA-4 transcripts, while blocking RARγ or RXRα diminishes nodal and Pitx2 transcripts; the expression of these genes in the heart forming region resembles that of the vitamin A-deficient embry…

Embryo NonmammalianTime Factorsanimal structuresCell SurvivalReceptors Retinoic Acidmedicine.drug_classMorphogenesisRetinoic acidRetinoid receptorCoturnixBiologyRetinoidschemistry.chemical_compoundmedicineAnimalsRNA MessengerRetinoidIn Situ HybridizationHomeodomain ProteinsGeneticsRetinoid X receptor alphaPITX2MyocardiumRetinoic Acid Receptor alphaGene Expression Regulation DevelopmentalOligonucleotides AntisenseGATA4 Transcription FactorCell biologyDNA-Binding ProteinsPhenotypeRetinoid X ReceptorschemistrySignal transductionNODALSignal TransductionTranscription FactorsDevelopmental BiologyDevelopmental Dynamics
researchProduct

The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes

1998

AbstractWe have studied the expression of the nuclear orphan receptor GCNF (germ cell nuclear factor) on the mRNA and protein level in pubertal and adult mouse testes. We show by Northern and Western blot analyses and by in situ hybridization that GCNF is expressed in spermatocytes and round spermatids of adult mouse testis suggesting that GCNF may be a transcriptional regulator of spermatogenesis. Since the GCNF protein is accumulated in the XY body of late pachytene spermatocytes, it may be involved in transcriptional inactivation of sex chromosomes.

MaleTranscription GeneticGerm cell nuclear factorBiophysicsFluorescent Antibody TechniqueReceptors Cytoplasmic and NuclearIn situ hybridizationBiologyIn Vitro TechniquesGerm cell nuclear factorBiochemistryEpitheliumMiceWestern blotStructural BiologySpermatocytesNuclear Receptor Subfamily 6 Group A Member 1TestisGeneticsTranscriptional regulationmedicineAnimalsRNA MessengerRetinoid receptor-related testis-associated receptorSpermatogenesisMolecular BiologyOrphan receptorMessenger RNAMice Inbred BALB Cmedicine.diagnostic_testCell BiologyMolecular biologySpermatidsNeuron-derived orphan receptor 1DNA-Binding ProteinsGene Expression RegulationNuclear orphan receptorSpermatogenesisNeuronal cell nuclear factorXY bodyFEBS Letters
researchProduct

Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by…

2003

The functional links of specific retinoid receptors to early developmental events in the avian embryo are not known. Before such studies are undertaken, knowledge is required of the spatiotemporal expression patterns of the receptor genes and their regulation by endogenous retinoic acid levels during the early stages of development. Here, we report the expression patterns of mRNAs for RARalpha, RARalpha2, RARbeta2, RARgamma, RARgamma2, RXRalpha, and RARgamma from neurulation to HH10 in the normal and vitamin A-deficient (VAD) quail embryo. The transcripts for all retinoid receptors are detectable at HH5, except for RXRgamma, which is detected at the beginning of HH6. At the 4/5 somite stage…

medicine.medical_specialtyEmbryo Nonmammaliananimal structuresTranscription GeneticReceptors Retinoic Acidmedicine.drug_classRetinoic acidRetinoid receptorTretinoinCoturnixRetinoid X receptorBiologyMicechemistry.chemical_compoundInternal medicinemedicineAnimalsRetinoidReceptorFetal DeathMolecular BiologyRetinoid X receptor alphaVitamin A DeficiencyRetinoic Acid Receptor alphaGene Expression Regulation DevelopmentalRetinal DehydrogenaseCell BiologyRetinoid X receptor gammaAldehyde OxidoreductasesCell biologyRetinoid X ReceptorsEndocrinologychemistryRetinoid X receptor betaTranscription FactorsDevelopmental BiologyDevelopmental Biology
researchProduct